The goal of the Central line infections (CLI) intervention is to implement a series of interdependent, scientifically grounded steps to reduce catheter-related blood stream infections. Central line infections (CLI) account for 90 per cent of catheter related infections and the mortality for central line-blood stream infections (BSI) is approximately 20 per cent. The intervention measures include: central line-associated blood stream infection (BSI) rate per 1000 central line days (Target: 50 per cent reduction), central line insertion bundle compliance and central line maintenance bundle compliance. The overall national mean for the Central Line-associated BSI rate per 1000 CLI days was reduced from a baseline of 5 to a sustained rate of 0.3 to 0.8 in Phase I. Of the teams reporting data, 75 per cent reached the national goal of <1.9 CLI-BSI per 1000 CLI days.